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dc.contributor.authorRezin, Gislaine Tezzapt_BR
dc.contributor.authorScaini, Gisellipt_BR
dc.contributor.authorGonçalves, Cinara L.pt_BR
dc.contributor.authorFerreira, Gabriela K.pt_BR
dc.contributor.authorCardoso, Mariane Ribeiropt_BR
dc.contributor.authorFerreira, Andréa Gisiane Kurekpt_BR
dc.contributor.authorCunha, Maira Jaqueline dapt_BR
dc.contributor.authorSchmitz, Felipept_BR
dc.contributor.authorVarela, Roger Bitencourtpt_BR
dc.contributor.authorQuevedo, João Luciano dept_BR
dc.contributor.authorWyse, Angela Terezinha de Souzapt_BR
dc.contributor.authorStreck, Emilio Luizpt_BR
dc.date.accessioned2015-03-28T01:57:39Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1516-4446pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/114598pt_BR
dc.description.abstractObjectives: Fenproporex is an amphetamine-based anorectic which is rapidly converted into amphetamine in vivo. Na+, K+-ATPase is a membrane-bound enzyme necessary to maintain neuronal excitability. Considering that the effects of fenproporex on brain metabolism are poorly known and that Na+, K+-ATPase is essential for normal brain function, this study sought to evaluate the effect of this drug on Na+, K+-ATPase activity in the hippocampus, hypothalamus, prefrontal cortex, and striatum of young rats. Methods: Young male Wistar rats received a single injection of fenproporex (6.25, 12.5, or 25 mg/kg intraperitoneally) or polysorbate 80 (control group). Two hours after the last injection, the rats were killed by decapitation and the brain was removed for evaluation of Na+, K+-ATPase activity. Results: Fenproporex decreased Na+, K+-ATPase activity in the striatum of young rats at doses of 6.25, 12.5, and 25 mg/kg and increased enzyme activity in the hypothalamus at the same doses. Na+, K+-ATPase activity was not affected in the hippocampus or prefrontal cortex. Conclusion: Fenproporex administration decreased Na+, K+-ATPase activity in the striatum even in low doses. However, in the hypothalamus, Na+, K+-ATPase activity was increased. Changes in this enzyme might be the result of the effects of fenproporex on neuronal excitability.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofRevista brasileira de psiquiatria = Brazilian journal of psychiatry. São Paulo. Vol. 36, no. 2 (abr./jun. 2014), p. 138-142pt_BR
dc.rightsOpen Accessen
dc.subjectATPase trocadora de sódio-potássiopt_BR
dc.subjectNa+en
dc.subjectK+-ATPase activityen
dc.subjectCérebropt_BR
dc.subjectAnfetaminaspt_BR
dc.subjectBrainen
dc.subjectFemproporexpt_BR
dc.subjectFenproporexen
dc.titleEvaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporexpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000937339pt_BR
dc.type.originNacionalpt_BR


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