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dc.contributor.authorQuatrin, Andréiapt_BR
dc.contributor.authorConte, Lisianept_BR
dc.contributor.authorSilva, Dariane Trivisiol dapt_BR
dc.contributor.authorFigueiredo, Cassiele Gpt_BR
dc.contributor.authorSomacal, Sabrinapt_BR
dc.contributor.authorRoehrs, Miguelpt_BR
dc.contributor.authorTeixeira, Cibele Ferreirapt_BR
dc.contributor.authorBarbisan, Fernandapt_BR
dc.contributor.authorAugusti, Paula Rossinipt_BR
dc.contributor.authorMaróstica Júnior, Máriopt_BR
dc.contributor.authorCruz, Ivana Beatrici Manica dapt_BR
dc.contributor.authorEmanuelli, Tatianapt_BR
dc.date.accessioned2021-08-18T04:31:37Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2090-0724pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/225799pt_BR
dc.description.abstractJaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. ,e aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of Nutrition and Metabolism. London. Vol. 2018, ID 9794629, 13 p.pt_BR
dc.rightsOpen Accessen
dc.subjectJabuticabapt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectCompostos bioativospt_BR
dc.subjectCarotenóidept_BR
dc.titleThe hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001074100pt_BR
dc.type.originEstrangeiropt_BR


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