Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies : analysis of the control arm of PATRICIA
dc.contributor.author | Castellsague, Xavier | pt_BR |
dc.contributor.author | Naud, Paulo Sergio Viero | pt_BR |
dc.contributor.author | Chow, Song-Nan | pt_BR |
dc.contributor.author | Wheeler, Cosette M. | pt_BR |
dc.contributor.author | Germar, Maria Julieta V. | pt_BR |
dc.contributor.author | Lehtinen, Matti | pt_BR |
dc.contributor.author | Paavonen, Jorma | pt_BR |
dc.contributor.author | Jaisamrarn, Unnop | pt_BR |
dc.contributor.author | Garland, Suzanne M. | pt_BR |
dc.contributor.author | Salmerón, Jorge | pt_BR |
dc.contributor.author | Apter, Dan L. | pt_BR |
dc.contributor.author | Kitchener, Henry | pt_BR |
dc.contributor.author | Teixeira, Júlio César | pt_BR |
dc.contributor.author | Skinner, S. Rachel | pt_BR |
dc.contributor.author | Limson, Genara | pt_BR |
dc.contributor.author | Szarewski, Anne | pt_BR |
dc.contributor.author | Romanowski, Barbara | pt_BR |
dc.contributor.author | Aoki, Fred Y. | pt_BR |
dc.contributor.author | Schwarz, Tino F. | pt_BR |
dc.contributor.author | Poppe, Willy A. J. | pt_BR |
dc.contributor.author | Bosch, F. Xavier | pt_BR |
dc.contributor.author | Carvalho, Newton S. de | pt_BR |
dc.contributor.author | Peters, Klaus | pt_BR |
dc.contributor.author | Tjalma, Wiebren A. A. | pt_BR |
dc.contributor.author | Safaeian, Mahboobeh | pt_BR |
dc.contributor.author | Raillard, Alice | pt_BR |
dc.contributor.author | Descamps, Dominique | pt_BR |
dc.contributor.author | Struyf, Frank | pt_BR |
dc.contributor.author | Dubin, Gary | pt_BR |
dc.contributor.author | Rosillon, Dominique | pt_BR |
dc.contributor.author | Baril, Laurence | pt_BR |
dc.contributor.author | HPV PATRICIA Study Group | pt_BR |
dc.date.accessioned | 2015-04-15T01:58:19Z | pt_BR |
dc.date.issued | 2014 | pt_BR |
dc.identifier.issn | 0022-1899 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/115351 | pt_BR |
dc.description.abstract | Background. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15–25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). Results. High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242–794), 204 (95% CI, 129–480), and 480 (95% CI, 250–5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. Conclusions. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | The Journal of infectious diseases. Oxford. Vol. 210, no. 4 (Aug. 2014), p. 517-534 | pt_BR |
dc.rights | Open Access | en |
dc.subject | HPV | en |
dc.subject | Papillomavirus humano 16 | pt_BR |
dc.subject | Naturally acquired antibodies | en |
dc.subject | Papillomavirus humano 18 | pt_BR |
dc.subject | Displasia do colo do útero | pt_BR |
dc.subject | Infection | en |
dc.subject | Cervical abnormality | en |
dc.subject | Risk reduction | en |
dc.title | Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies : analysis of the control arm of PATRICIA | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000953416 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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