Browsing Biological Sciences by Author "Egan, Lauren"

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    • GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation 

      Carlessi, Rodrigo Maron; Chen, Younan; Rowlands, Jordan; Cruzat, Vinicius Fernandes; Keane, Kevin Noel; Egan, Lauren; Mamotte, Cyril; Stokes, Rebecca; Gunton, Jenny E.; Bittencourt Junior, Paulo Ivo Homem de; Newsholme, Philip (2016) [Journal article]
      Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent ...