• Antibiofilm activity of Cobetia marina filtrate upon Staphylococcus epidermidis catheter-related isolates 

      Trentin, Danielle da Silva; Gorziza, Daniela Fernandes; Abraham, Wolf Rainer; Antunes, Ana Lucia Souza; Lerner, Cléa Beatriz; Mothes, Beatriz; Termignoni, Carlos; Macedo, Alexandre José (2011) [Artigo de periódico]
      We report the antibiofilm activity by the sponge-associated bacterium Cobetia marina upon Staphylococcus epidermidis clinical isolates obtained from central venous catheters. Antibiofilm activity/antimicrobial susceptibility ...
    • Antimicrobial activity and phytochemical screening of buchenavia tetraphylla (aubl.) R. A. Howard (combretaceae: combretoideae) 

      Oliveira, Ygor Lucena Cabral de; Silva, Luís Cláudio Nascimento da; Silva, Alexandre Gomes da; Macedo, Alexandre José; Araújo, Janete Magali; Correia, Maria Tereza dos Santos; Silva, Márcia Vanusa da (2012) [Artigo de periódico]
      This study evaluated the antimicrobial and hemolytic activities and phytochemical constituents of hydroalcoholic extract and its fractions from Buchenavia tetraphylla leaves. Cyclohexane (BTCF), ethyl acetate (BTEF), and ...
    • Capsicumicine, a new bioinspired peptide from red peppers prevents staphylococcal biofilm in vitro and in vivo via a matrix anti-assembly mechanism of action 

      Von Borowski, Rafael Gomes; Chat, Sophie; Schneider, Rafael de Oliveira; Nonin-Lecomte, Sylvie; Bouaziz, Serge; Giudice, Emmanuel; Zimmer, Aline Rigon; Gnoatto, Simone Cristina Baggio; Macedo, Alexandre José; Gillet, Reynald (2021) [Artigo de periódico]
      Staphylococci are pathogenic biofilm-forming bacteria and a source of multidrug resistance and/or tolerance causing a broad spectrum of infections. These bacteria are enclosed in a matrix that allows them to colonize medical ...
    • Comparison of techniques for counting prokaryotes in marine planktonic and biofilm samples 

      Agostini, Vanessa Ochi; Rodrigues, Letícia Terres; Macedo, Alexandre José; Muxagata, Erik (2021) [Artigo de periódico]
      Though a large number of techniques are available for the study of aquatic bacteria, the aim of this study was to establish a technique for analysing free-living and biofilm prokaryotic cells through laboratory assays. In ...
    • Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria 

      Silva, Dayse Pereira Dias; Cardoso, Macley Silva; Macedo, Alexandre José (2022) [Artigo de periódico]
      Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly ...
    • Enzimas microbianas de uso terapêutico e diagnóstico clínico 

      Zimmer, Karine Rigon; Borré, Gustavo Luís; Trentin, Danielle da Silva; Woicickoski Júnior, Clóvis; Frasson, Amanda Piccoli; Graeff, Alexandre de Arruda; Gomes, Patricia; Macedo, Alexandre José (2009) [Artigo de periódico]
      Enzimas microbianas têm se destacado como um dos principais produtos tecnológicos do mundo moderno, porém seu uso tem relatos nos tempos mais remotos. No início do século XX, teve início a produção em grande escala de ...
    • Estrategias de control de mejillones invasores : una revisión 

      Pereira, Mikael Luiz Morales; Vasconcelos, Ivna Maria Bastos; Macedo, Alexandre José; Muxagata, Erik; Pinho, Grasiela Lopes Leães; Agostini, Vanessa Ochi (2022) [Artigo de periódico]
      El proceso de bioincrustación puede dañar varias estructuras construidas por el hombre y, junto con el agua de lastre, es el principal vector para la transferencia de especies invasoras en todo el mundo. El control de las ...
    • Estratégias e desafios no combate à malária 

      Frasson, Amanda Piccoli; Barlette, Adriana Gregory; Dalpizolo, Cristiano; Sauter, Ismael Pretto; Macedo, Alexandre José; Tasca, Tiana (2009) [Artigo de periódico]
      A malária é uma das mais importantes doenças parasitárias do mundo, apresentando como agente etiológico protozoários do gênero Plasmodium. Dados recentes apontam que aproximadamente 40% da população mundial está exposta à ...
    • Evaluation of antibiotics as a methodological procedure to inhibit free-living and biofilm bacteria in marine zooplankton culture 

      Agostini, Vanessa Ochi; Macedo, Alexandre José; Muxagata, Erik (2016) [Artigo de periódico]
      There is a problem with keeping culture medium completely or partially free from bacteria. The use of prokaryotic metabolic inhibitors, such as antibiotics, is suggested as an alternative solution, although such substances ...
    • High microbiome variability in pediatric tracheostomy cannulas in patients with similar clinical characteristics 

      Kuhl, Leonardo Palma; Marostica, Paulo José Cauduro; Macedo, Alexandre José; Kuhl, Gabriel; Siebert, Marina; Manica, Denise; Sekine, Leo; Schweiger, Claudia (2023) [Artigo de periódico]
      Objectives To evaluate the bacterial microbiome found in tracheostomy cannulas of a group of children diagnosed with glossoptosis secondary to Robin Sequence (RS), and its clinical implications. Methods Pediatric patients ...
    • High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters 

      Antunes, Ana Lucia Souza; Bonfanti, Jéssica Weis; Perez, Leandro Reus Rodrigues; Pinto, Camille Catani Ferreira; Freitas, Ana Lucia Peixoto de; Macedo, Alexandre José; Barth, Afonso Luis (2011) [Artigo de periódico]
      Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. ...
    • Intestinal parasitism and socio-environmental factors among mbyá-guarani indians, Porto Alegre, Rio Grande do Sul, Brazil 

      Brandelli, Clara Lia Costa; De Carli, Geraldo Attilio; Macedo, Alexandre José; Tasca, Tiana (2012) [Artigo de periódico]
      Dados preocupantes demonstram a prevalência de parasitos intestinais e sua relação com fatores socioambientais entre indígenas Mbya-Guarani. A prevalência foi determinada pelas técnicas de sedimentação espontânea em água, ...
    • Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis 

      Vieira, Patrícia de Brum; Silva, Nícolas Luiz Feijó; Kist, Luiza Wilges; Oliveira, Giovanna Medeiros Tavares de; Bogo, Mauricio Reis; Carli, Geraldo Attilio de; Macedo, Alexandre José; Tasca, Tiana (2015) [Artigo de periódico]
      Extracellular ATP may act as a danger signalling molecule, inducing inflammation and immune responses in infection sites. The ectonucleotidases NTPDase and ecto-5’-nucleotidase are enzymes that modulate extracellular ...
    • Macrocolony of NDM-1 producing Enterobacter hormaechei subsp. oharae generates subpopulations with different features regarding the response of antimicrobial agents and biofilm formation 

      Brust, Flavia Roberta; Boff, Luana; Trentin, Danielle da Silva; Rozales, Franciéli Pedrotti; Barth, Afonso Luis; Macedo, Alexandre José (2019) [Artigo de periódico]
      Enterobacter cloacae complex has been increasingly recognized as a nosocomial pathogen representing the third major Enterobacteriaceae species involved with infections. This study aims to evaluate virulence and antimicrobial ...
    • Marine biotechnology in Brazil : recent developments and its potential for innovation 

      Thompson, Fabiano L.; Kruger, Ricardo Henrique; Thompson, Cristiane Carneiro; Berlinck, Roberto G. S.; Coutinho, Ricardo; Landell, Melissa Fontes; Pavão, Mauro Sérgio Gonçalves; Mourão, Paulo Antônio de Souza; Salles, Ana; Negri, Naiane Barreto; Lopes, Fabyano Alvares Cardoso; Freire, Vítor Fernandes; Macedo, Alexandre José; Maraschin, Marcelo; Pérez, Carlos Daniel; Pereira, Renato Crespo; Baptista, Gandhi Rádis; Rezende, Rachel Passos; Valenti, Wagner Cotroni; Abreu, Paulo Cesar Oliveira Vergne de (2018) [Artigo de periódico]
      Marine biotechnology is an emerging field in Brazil and includes the exploration of marine microbial products, aquaculture, omics, isolation of biologically active compounds, identification of biosynthetic gene clusters ...
    • Microrganismos em favor da saúde humana 

      Carvalho, Maira Peres de; Abraham, Wolf Rainer; Macedo, Alexandre José (2008) [Artigo de periódico]
      Os fungos e as bactérias possuem um enorme potencial de produção de compostos biologicamente ativos que podem e são utilizados no tratamento de várias enfermidades humanas. Destaca-se, nesta breve revisão, a importância ...
    • Modulatory effect of iron chelators on adenosine deaminase activity and gene expression in Trichomonas vaginalis 

      Barros, Muriel Primon de; Rigo, Graziela de Vargas; Frasson, Amanda Piccoli; Santos, Odelta dos; Smiderle, Lisiane; Almeida, Silvana Maria de; Macedo, Alexandre José; Tasca, Tiana (2015) [Artigo de periódico]
      Trichomonas vaginalis is a flagellate protozoan that parasitises the urogenital human tract and causes trichomoniasis. During the infection, the acquisition of nutrients, such as iron and purine and pyrimidine nucleosides, ...
    • Myricetin protects Galleria mellonella against Staphylococcus aureus infection and inhibits multiple virulence factors 

      Silva, Laura Nunes; Hora, Gabriel Costa Alverni da; Silva, Thereza Amélia Soares da; Bojer, Martin Saxtorph; Ingmer, Hanne; Macedo, Alexandre José; Trentin, Danielle da Silva (2017) [Artigo de periódico]
      Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. We report here that myricetin, but not its ...
    • A new Kunitz trypsin inhibitor from Erythrina poeppigiana exhibits antimicrobial and antibiofilm properties against bacteria 

      Barros, Karina Margareti Alencar de; Sardi, Janaina de Cássia Orlandi; Neto, Simone Maria; Macedo, Alexandre José; Ramalho, Suellen Rodrigues; Oliveira, Daniella Gorete Lourenço de; Pontes, Gemilson Soares; Weber, Simone Schneider; Oliveira, Caio Fernando Ramalho de; Macedo, Maria Lígia Rodrigues (2021) [Artigo de periódico]
      Erythrina poeppigiana belongs to Fabaceae family (subfamily Papillionoideae) and is commonly found in tropical and subtropical regions in Brazil. Herein, we described the purification and characterization of a new Kunitz-type ...
    • Optimal reference genes for gene expression normalization in Trichomonas vaginalis 

      Santos, Odelta dos; Rigo, Graziela de Vargas; Frasson, Amanda Piccoli; Macedo, Alexandre José; Tasca, Tiana (2015) [Artigo de periódico]
      Trichomonas vaginalis is the etiologic agent of trichomonosis, the most common non-viral sexually transmitted disease worldwide. This infection is associated with several health consequences, including cervical and prostate ...