Navegação Ciências da Saúde por Autor "Wagner, Vivian Petersen"

Resultados 1-10 de 10

    • A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay 

      Olivera, Maria Laura Cosetti; Wagner, Vivian Petersen; Sant'Ana Filho, Manoel; Carrard, Vinícius Coelho; Hugo, Fernando Neves; Martins, Manoela Domingues (2015) [Artigo de periódico]
      The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical ...

    • Drug-based therapy for advanced adenoid cystic carcinoma : current landscape and challenges based on an overview of registered clinical trials 

      Wagner, Vivian Petersen; Ferrarotto, Renata; Vargas, Pablo Agustin; Martins, Manoela Domingues; Bingle, Colin D.; Bingle, Lynne (2023) [Artigo de periódico]
      Adenoid cystic carcinoma (ACC) has a significant patient-population in need of effective systemic therapy, as no drug is currently approved by the FDA for its management. We critically reviewed ACC-clinical trials (CT) ...

    • Effects of a mucoadhesive formulation containing Curcuma Longa L. on oral wound healing 

      Danilevicz, Chris Krebs; Wagner, Vivian Petersen; Webber, Liana Preto; Schmidt, Tuany Rafaeli; Alonso, Ellen Cristine Pineze; Mendonca, Elismauro Francisco de; Valadares, Marize Campos; Marreto, Ricardo Neves; Martins, Manoela Domingues (2020) [Artigo de periódico]
      Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned ...

    • Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels 

      Kim, Hong Sun; Chen, Yu-Chih; Nör, Felipe; Warner, Kristy; Andrews, April; Wagner, Vivian Petersen; Zhang, Zhaocheng; Zhang, Zhixiong; Martins, Manoela Domingues; Pearson, Alexander T.; Yoon, Euisik; Nor, Jacques Eduardo (2017) [Artigo de periódico]
      Recent evidence suggests that the metastatic spread of head and neck squamous cell carcinomas (HNSCC) requires the function of cancer stem cells endowed with multipotency, self-renewal, and high tumorigenic potential. We ...

    • Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis 

      Wagner, Vivian Petersen; Martins, Marco Antonio Trevizani; Martins, Manoela Domingues; Warner, Kristy; Webber, Liana Preto; Squarize, Cristiane Helena; Nor, Jacques Eduardo; Castilho, Rogerio Moraes (2016) [Artigo de periódico]
      Patients with mucoepidermoid carcinoma (MEC) experience low survival rates and high morbidity following treatment, yet the intrinsic resistance of MEC cells to ionizing radiation (IR) and the mechanisms underlying acquired ...

    • Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure 

      Spuldaro, Tobias Rauber; Wagner, Vivian Petersen; Nör, Felipe; Gaio, Eduardo José; Squarize, Cristiane Helena; Carrard, Vinícius Coelho; Rösing, Cassiano Kuchenbecker; Castilho, Rogerio Moraes (2022) [Artigo de periódico]
      For decades, the link between poor oral hygiene and the increased prevalence of oral cancer has been suggested. Most recently, emerging evidence has suggested that chronic inflammatory diseases from the oral cavity (e.g., ...

    • Risk factors for jaw osteoradionecrosis : a case control study 

      Girardi, Fábio Muradas; Wagner, Vivian Petersen; Martins, Manoela Domingues; Abentroth, Aliende Lengler; Hauth, Luiz Alberto; Kraether Neto, Léo; Mergen, Cristian; Matiello, Juliana (2022) [Artigo de periódico]
      There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a ...

    • Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas 

      Wagner, Vivian Petersen; Martins, Manoela Domingues; Martins, Marco Antonio Trevizani; Almeida, Luciana Oliveira; Warner, Kristy; Nor, Jacques Eduardo; Squarize, Cristiane Helena; Castilho, Rogerio Moraes (2018) [Artigo de periódico]
      Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharyngeal anatomical area. Mucoepidermoid Carcinomas (MEC) is the most common malignancy from the salivary glands. Low survival ...

    • TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma : an immunohistochemical study 

      Weissheimer, Camila; Wagner, Vivian Petersen; Webber, Liana Preto; Santos, Jean Nunes dos; Sant'Ana Filho, Manoel; Meurer, Luíse; Martins, Marco Antonio Trevizani; Martins, Manoela Domingues (2018) [Artigo de periódico]
      Introduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) ...

    • TrkB-targeted therapy for mucoepidermoid carcinoma 

      Wagner, Vivian Petersen; Martins, Manoela Domingues; Amoura, Esra; Zanella, Virgilio Gonzales; Roesler, Rafael; De-Farias, Caroline Brunetto; Bingle, Colin D.; Vargas, Pablo Agustin; Bingle, Lynne (2020) [Artigo de periódico]
      The brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase B (TrkB) pathway was previously associated with key oncogenic outcomes in a number of adenocarcinomas. The aim of our study was to determine the role ...