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dc.contributor.authorMarchetti, Desirèe Padilhapt_BR
dc.contributor.authorRibas, Graziela de Oliveira Schmittpt_BR
dc.contributor.authorDonida, Brunapt_BR
dc.contributor.authorBrito, Verônica Bidinottopt_BR
dc.contributor.authorMoura, Dinara Jaquelinept_BR
dc.contributor.authorCoelho, Daniella de Mourapt_BR
dc.contributor.authorMachado, Andryele Zaffaript_BR
dc.contributor.authorKessler, Rejane Guspt_BR
dc.contributor.authorCoitinho, Adriana Simonpt_BR
dc.contributor.authorVargas, Carmen Reglapt_BR
dc.date.accessioned2021-08-05T04:31:10Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2357-9730pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/225215pt_BR
dc.description.abstractIntroduction: Several studies in the literature have evaluated the role of oxidative stress and adjuvant therapies for X-linked adrenoleukodystrophy (X-ALD). Here, we investigated whether n-acetyl-L-cysteine (NAC) and rosuvastatin (RSV) could influence the generation of reactive species, redox status and nitrative stress in fibroblasts from asymptomatic patients with X-ALD. Methods: Skin biopsy samples were cultured and treated for 2 hours (37 °C) with NAC and RSV. Results: X-ALD fibroblasts generated high levels of reactive oxygen species. These levels were significantly lower in fibroblasts treated with NAC and RSV relative to untreated samples. The X-ALD fibroblasts from asymptomatic patients also had higher catalase activity, and only NAC was able to increase enzyme activity in the samples. Conclusions: Our results indicated that NAC and RSV were able to improve oxidative stress parameters in fibroblasts from asymptomatic patients with X-ALD, showing that adjuvant antioxidant therapy may be a promising treatment strategy for asymptomatic patients with this disease.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical and biomedical research. Porto Alegre. vol. 41, no. 1 (2021), p. 57-64pt_BR
dc.rightsOpen Accessen
dc.subjectEstresse oxidativopt_BR
dc.subjectX-linked adrenoleukodystrophyen
dc.subjectAcetilcisteínapt_BR
dc.subjectFibroblastsen
dc.subjectAdrenoleucodistrofiapt_BR
dc.subjectN-acetyl-L-cysteineen
dc.subjectRosuvastatinen
dc.subjectRosuvastatina cálcicapt_BR
dc.subjectOxidative stressen
dc.titleProtective effect of N-acetyl-L-cysteine and rosuvastatin against oxidative stress in fibroblasts from asymptomatic patients with X-ALD : a preliminary studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001129131pt_BR
dc.type.originNacionalpt_BR


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