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dc.contributor.authorFernandes, Michel Ribeiropt_BR
dc.contributor.authorGhezzi, Caroline Lorenzoni Almeidapt_BR
dc.contributor.authorGrezzana Filho, Tomáz de Jesus Mariapt_BR
dc.contributor.authorFeier, Flávia Heinzpt_BR
dc.contributor.authorLeipnitz, Ianpt_BR
dc.contributor.authorChedid, Aljamir Duartept_BR
dc.contributor.authorCerski, Carlos Thadeu Schmidtpt_BR
dc.contributor.authorChedid, Márcio Fernandespt_BR
dc.contributor.authorKruel, Cleber Rosito Pintopt_BR
dc.date.accessioned2021-09-01T04:24:37Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1948-9366pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/229314pt_BR
dc.description.abstractBACKGROUND Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect. Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care. However, under specific circumstances, a cytoreductive approach may represent a therapeutic option. We describe herein the case of an 84-year-old woman who presented with a tender, protruding epigastric mass. Abdominal computed tomography scan revealed a large, heterogeneous mass located across segments III, IV, V, and VIII of the liver. The initial approach was transarterial embolization of the tumor, which elicited no appreciable response. Considering the large size and central location of the tumor and the advanced age of the patient, non-anatomic complete resection was indicated. Due to substantial intraoperative bleeding and hemodynamic instability, only a near-complete resection could be achieved. Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver. Considering the risk/benefit ratio for therapeutic options, debulking surgery may represent a strategy to control pain and prolong survival. CASE SUMMARY Here, we present a case report of a patient diagnosed with E-GIST primary of the liver, which was indicated a cytoreductive surgery and adjuvant therapy with imatinib. CONCLUSION E-GIST primary of the liver is a rare conditional, the treatment is with systemic therapy and total resection surgery. However, a cytoreductive surgery will be necessary when a complete resection is no possible.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofWorld journal of gastrointestinal surgery. Beijing. Vol. 13, no. 3 (Mar. 2021), p. 315-322.pt_BR
dc.rightsOpen Accessen
dc.subjectNeoplasias gastrointestinaispt_BR
dc.subjectExtra-gastrointestinal stromal tumoren
dc.subjectTumores do estroma gastrointestinalpt_BR
dc.subjectPrimary gastrointestinal stromal tumor of the liveren
dc.subjectProcedimentos cirúrgicos de citorreduçãopt_BR
dc.subjectCytoreductive surgeryen
dc.subjectDebulking surgeryen
dc.subjectRelatos de casospt_BR
dc.subjectCase reporten
dc.titleGiant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy : a case report and review of literaturept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001130143pt_BR
dc.type.originEstrangeiropt_BR


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