TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma : an immunohistochemical study
dc.contributor.author | Weissheimer, Camila | pt_BR |
dc.contributor.author | Wagner, Vivian Petersen | pt_BR |
dc.contributor.author | Webber, Liana Preto | pt_BR |
dc.contributor.author | Santos, Jean Nunes dos | pt_BR |
dc.contributor.author | Sant'Ana Filho, Manoel | pt_BR |
dc.contributor.author | Meurer, Luíse | pt_BR |
dc.contributor.author | Martins, Marco Antonio Trevizani | pt_BR |
dc.contributor.author | Martins, Manoela Domingues | pt_BR |
dc.date.accessioned | 2021-10-15T04:26:39Z | pt_BR |
dc.date.issued | 2018 | pt_BR |
dc.identifier.issn | 2357-9730 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/230773 | pt_BR |
dc.description.abstract | Introduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity, and patients’ prognosis. Methods: A total of 68 patients with histopathological diagnosis of OSCC were included, as well as 9 cases of normal oral mucosa for comparison purposes. The OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 were performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively. Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival. Conclusions: TGF-β1 had no prognostic value and appears to maintain its suppressive role concerning cell proliferation. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Clinical and biomedical research. Porto Alegre. Vol. 38, no. 4 (2018), p. 316-323 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Head and neck neoplasms | en |
dc.subject | Neoplasias de cabeça e pescoço | pt_BR |
dc.subject | Prognóstico | pt_BR |
dc.subject | Prognosis | en |
dc.subject | Fatores de crescimento transformadores | pt_BR |
dc.subject | Transforming growth factors | en |
dc.title | TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma : an immunohistochemical study | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001131850 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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