Increased frequency of blaNDM in a tertiary care hospital in Southern Brazil
dc.contributor.author | Wink, Priscila Lamb | pt_BR |
dc.contributor.author | Martins, Amanda Silva | pt_BR |
dc.contributor.author | Volpato, Fabiana Caroline Zempulski | pt_BR |
dc.contributor.author | Zavascki, Alexandre Prehn | pt_BR |
dc.contributor.author | Barth, Afonso Luis | pt_BR |
dc.date.accessioned | 2021-10-15T04:27:25Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 1517-8382 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/230809 | pt_BR |
dc.description.abstract | Resistance to carbapenems due to metallo-beta-lactamase NDM-1 was first described in Brazil in 2013. To date, only a few scattered reports of the prevalence of NDM-1 in the country have been reported, and most of them indicated a very low prevalence of this metalloenzyme. In the present study, we report a steady increase in the frequency of NDM among Enterobacterales resistant to carbapenems in a tertiary care hospital in southern Brazil. Carbapenemase genes were evaluated by multiplex real-time polymerase chain using high-resolution melting analysis among 3501 isolates of 8 different species of Enterobacterales recovered from January 2015 to May 2020. The blaKPC-like was identified in 3003 isolates (85.8%) and the blaNDM-like was the second most common gene (351 isolates—10%). There was a steady increase in frequency of blaNDM-like, from 4.2% in 2015 to 24%in 2020. The increase of blaNDM frequency raises an important matter as novel therapeutic options are currently very limited for the treatment of patients infected by bacteria carrying the blaNDM. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of microbiology. São Paulo. vol. 52, no. 1 (2021), p. 299-301 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Beta-lactamases | pt_BR |
dc.subject | Carbapenemase | en |
dc.subject | Dissemination | en |
dc.subject | Carbapenêmicos | pt_BR |
dc.subject | NDM-1 | en |
dc.subject | Farmacorresistência bacteriana múltipla | pt_BR |
dc.subject | New Delhi metallo-beta-lactamase | en |
dc.subject | Resistance | en |
dc.title | Increased frequency of blaNDM in a tertiary care hospital in Southern Brazil | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001131646 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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