Phenolic compounds of red wine aglianico del vulture modulate the functional activity of macrophages via inhibition of NF-κB and the citrate pathway
dc.contributor.author | Santarsiero, Anna | pt_BR |
dc.contributor.author | Convertini, Paolo | pt_BR |
dc.contributor.author | Vassallo, Antonio | pt_BR |
dc.contributor.author | Santoro, Valentina | pt_BR |
dc.contributor.author | Todisco, Simona | pt_BR |
dc.contributor.author | Iacobazzi, Dominga | pt_BR |
dc.contributor.author | Fondufe-Mittendorf, Yvonne | pt_BR |
dc.contributor.author | Martelli, Giuseppe | pt_BR |
dc.contributor.author | Oliveira, Marcos Roberto de | pt_BR |
dc.contributor.author | Montanaro, Rosangela | pt_BR |
dc.contributor.author | Brancaleone, Vincenzo | pt_BR |
dc.contributor.author | Stöckl, Johannes | pt_BR |
dc.contributor.author | Infantino, Vittoria | pt_BR |
dc.date.accessioned | 2021-10-20T04:23:13Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 1942-0994 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/230964 | pt_BR |
dc.description.abstract | Phenolic compounds of red wine powder (RWP) extracted from the Italian red wine Aglianico del Vulture have been investigated for the potential immunomodulatory and anti-inflammatory capacity on human macrophages. These compounds reduce the secretion of IL-1β, IL-6, and TNF-α proinflammatory cytokines and increase the release of IL-10 anti-inflammatory cytokine induced by lipopolysaccharide (LPS). In addition, RWP restores Annexin A1 levels, thus involving activation of proresolutive pathways. Noteworthy, RWP lowers NF-κB protein levels, promoter activity, and nuclear translocation. As a consequence of NF-κB inhibition, reduced promoter activities of SLC25A1—encoding the mitochondrial citrate carrier (CIC)—and ATP citrate lyase (ACLY) metabolic genes have been observed. CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO⋅, and PGE2 inflammatory mediators. We identify the citrate pathway as a RWP target in carrying out its anti-inflammatory activity since RWP reduces CIC and ACLY protein levels, ACLY enzymatic activity, the cytosolic citrate concentration, and in turn ROS, NO⋅, PGE2, and histone acetylation levels. Overall findings suggest that RWP potentially restores macrophage homeostasis by suppressing inflammatory pathways and activating proresolutive processes. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Oxidative medicine and cellular longevity. New York. Vol. 2021 (2021), 5533793, 15 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Vinho | pt_BR |
dc.subject | Compostos fenólicos | pt_BR |
dc.subject | NF-kappa B | pt_BR |
dc.subject | Ácido cítrico | pt_BR |
dc.subject | Macrófagos | pt_BR |
dc.title | Phenolic compounds of red wine aglianico del vulture modulate the functional activity of macrophages via inhibition of NF-κB and the citrate pathway | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001132132 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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