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dc.contributor.authorSekine, Leopt_BR
dc.contributor.authorArns, Beatrizpt_BR
dc.contributor.authorFabro, Bruna Rosapt_BR
dc.contributor.authorCipolat, Murillo Machadopt_BR
dc.contributor.authorMachado, Rafael Rahal Guaragnapt_BR
dc.contributor.authorDurigon, Edison Luizpt_BR
dc.contributor.authorParolo, Edinopt_BR
dc.contributor.authorPellegrini, José Augusto Santospt_BR
dc.contributor.authorViana, Marina Verçozapt_BR
dc.contributor.authorSchwarz, Patríciapt_BR
dc.contributor.authorLisboa, Thiago Costapt_BR
dc.contributor.authorDora, José Miguel Silvapt_BR
dc.contributor.authorPortich, Julia Plentzpt_BR
dc.contributor.authorPaz, Alessandra Aparecidapt_BR
dc.contributor.authorSilla, Lucia Mariano da Rochapt_BR
dc.contributor.authorBalsan, Almeri Marlenept_BR
dc.contributor.authorSchirmer, Felippe da Silvapt_BR
dc.contributor.authorFranz, Juliana Pires Marafonpt_BR
dc.contributor.authorSilveira, Luciana M. dapt_BR
dc.contributor.authorBreunig, Raquel Cristinept_BR
dc.contributor.authorPetersen, Vivianapt_BR
dc.contributor.authorSosnoski, Monalisapt_BR
dc.contributor.authorMesquita, Nanci Felixpt_BR
dc.contributor.authorVolpato, Fabiana Caroline Zempulskipt_BR
dc.contributor.authorSganzerla, Danielpt_BR
dc.contributor.authorFalavigna, Maiconpt_BR
dc.contributor.authorRosa, Regis Goulartpt_BR
dc.contributor.authorZavascki, Alexandre Prehnpt_BR
dc.contributor.authorOliveira, Ana Claudia Tonelli dept_BR
dc.contributor.authorMalaquias, Andreia Rochapt_BR
dc.contributor.authorSilva, Ane Katiussa Siqueira Fröhlic dapt_BR
dc.contributor.authorAraujo, Anelise Bergmannpt_BR
dc.contributor.authorAraújo Antônia Cícera da Silvapt_BR
dc.contributor.authorBlos, Brunapt_BR
dc.contributor.authorCohen, Carolina Rodriguespt_BR
dc.contributor.authorBorges, Cristiane Tavarespt_BR
dc.contributor.authorRocha, Cristiano Rossa dapt_BR
dc.contributor.authorSperansa, Daniela Michelim Rodriguezpt_BR
dc.contributor.authorOliveira, Delany da Silvapt_BR
dc.contributor.authorRados, Dimitris Rucks Varvakipt_BR
dc.contributor.authorBonacina, Francinept_BR
dc.contributor.authorSalton, Gabrielle Diaspt_BR
dc.contributor.authorZucchetti, Giovanapt_BR
dc.contributor.authorFreitas, Isabel Cristinapt_BR
dc.contributor.authorConstante, Juliana Goncalvespt_BR
dc.contributor.authorFurlan, Juliana Monteiropt_BR
dc.contributor.authorKleber, Karinept_BR
dc.contributor.authorVieira, Laís Pelentierpt_BR
dc.contributor.authorPires, Leonardo Martinspt_BR
dc.contributor.authorRöhsig, Liane Marisept_BR
dc.contributor.authorVargas, Luciana do Nascimentopt_BR
dc.contributor.authorLeão, Marize do Socorro Vulcãopt_BR
dc.contributor.authorAngeli, Melissa Helenapt_BR
dc.contributor.authorSeltenreich, Patricia Paim Ferreirapt_BR
dc.contributor.authorSilva, Patricia Santos dapt_BR
dc.contributor.authorScheffel, Rafael Selbachpt_BR
dc.contributor.authorBoehm, Renata Elianept_BR
dc.contributor.authorMello, Renato Gorga Bandeira dept_BR
dc.contributor.authorSouza, Thabyta Silva Franco dept_BR
dc.date.accessioned2022-04-13T04:52:07Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn0903-1936pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/237199pt_BR
dc.description.abstractBackground: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe European respiratory journal. Sheffield. Vol. 59 (2022), 2101471, 11 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCOVID-19pt_BR
dc.titleConvalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trialpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001138081pt_BR
dc.type.originEstrangeiropt_BR


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