Ionic liquid-loaded microcapsules doped into dental resin infiltrants
dc.contributor.author | Cuppini, Marla | pt_BR |
dc.contributor.author | Garcia, Isadora Martini | pt_BR |
dc.contributor.author | Souza, Virgínia Serra de | pt_BR |
dc.contributor.author | Zatta, Kelly Cristine | pt_BR |
dc.contributor.author | Visioli, Fernanda | pt_BR |
dc.contributor.author | Leitune, Vicente Castelo Branco | pt_BR |
dc.contributor.author | Guterres, Silvia Stanisçuaski | pt_BR |
dc.contributor.author | Scholten, Jackson Damiani | pt_BR |
dc.contributor.author | Collares, Fabrício Mezzomo | pt_BR |
dc.date.accessioned | 2022-07-15T04:48:29Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 2452-199X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/242567 | pt_BR |
dc.description.abstract | Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, we developed a novel resin infiltrant with microcapsules loaded with an ionic liquid (MC-IL), and analyzed the physical properties and cytotoxicity of the dental resin. First, the ionic liquid 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMI.NTf2) was synthesized. BMI.NTf2 has previously shown antibacterial activity in a dental resin. Then, MC-IL were synthesized by the deposition of a preformed polymer. The MC-IL were analyzed for particle size and de-agglomeration effect via laser diffraction analysis and shape via scan ning electron microscopy (SEM). The infiltrants were formulated, and the MC-IL were incorporated at 2.5%, 5%, and 10 wt%. A group without MC-IL was used as a control. The infiltrants were evaluated for ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity. The MC-IL showed a mean particle size of 1.64 (±0.08) μm, shriveled aspect, and a de-agglomeration profile suggestive of nanoparticles’ presence in the synthesized powder. There were no differences in UTS among groups (p > 0.05). The incorporation of 10 wt% of MC-IL increased the contact angle (p < 0.05), while the addition from 5 wt% reduced the SFE in comparison to the control group (p < 0.05). The human cell viability was above 90% for all groups (p > 0.05). The incorpo ration of microcapsules as a drug-delivery system for ionic liquids may be a promising strategy to improve dental restorative materials. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Bioactive materials. Beijing. Vol. 6, no. 9 (2021), p.2667-2675 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Propriedades de superfície | pt_BR |
dc.subject | Surface properties | en |
dc.subject | Dental caries | en |
dc.subject | Cárie dentária | pt_BR |
dc.subject | Sistemas de liberação de medicamentos | pt_BR |
dc.subject | Drug delivery systems | en |
dc.subject | Polymers | en |
dc.subject | Polímeros | pt_BR |
dc.title | Ionic liquid-loaded microcapsules doped into dental resin infiltrants | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001142005 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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