Associations between exploratory dietary patterns and incident type 2 diabetes : a federated meta-analysis of individual participant data from 25 cohort studies
dc.contributor.author | Jannasch, Franziska | pt_BR |
dc.contributor.author | Luft, Vivian Cristine | pt_BR |
dc.contributor.author | Schulze, Matthias B. | pt_BR |
dc.date.accessioned | 2022-10-26T04:49:48Z | pt_BR |
dc.date.issued | 2022 | pt_BR |
dc.identifier.issn | 1436-6215 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/250363 | pt_BR |
dc.description.abstract | Purpose In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, fndings remained study-specifc, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world. Methods This federated meta-analysis of individual participant data was based on 25 prospective cohort studies from 5 continents including a total of 390,664 participants with a follow-up for T2D (3.8–25.0 years). After data harmonization across cohorts we evaluated 15 previously identifed T2D-related DPs for association with incident T2D estimating pooled incidence rate ratios (IRR) and confdence intervals (CI) by Piecewise Poisson regression and random-efects meta-analysis. Results 29,386 participants developed T2D during follow-up. Five DPs, characterized by higher intake of red meat, processed meat, French fries and refned grains, were associated with higher incidence of T2D. The strongest association was observed for a DP comprising these food groups besides others (IRRpooled per 1 SD=1.104, 95% CI 1.059–1.151). Although heterogeneity was present (I 2=85%), IRR exceeded 1 in 18 of the 20 meta-analyzed studies. Original DPs associated with lower T2D risk were not confrmed. Instead, a healthy DP (HDP1) was associated with higher T2D risk (IRRpooled per 1 SD=1.057, 95% CI 1.027–1.088). Conclusion Our fndings from various cohorts revealed positive associations for several DPs, characterized by higher intake of red meat, processed meat, French fries and refned grains, adding to the evidence-base that links DPs to higher T2D risk. However, no inverse DP–T2D associations were confrmed. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | European journal of nutrition. Darmstadt. Vol. 61 (2022), p. 3649-3667. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Diabetes mellitus tipo 2 | pt_BR |
dc.subject | Dietary patterns | en |
dc.subject | Exploratory | en |
dc.subject | Metanálise | pt_BR |
dc.subject | Type 2 diabetes mellitus | en |
dc.subject | Dieta | pt_BR |
dc.subject | Federated meta-analysis | en |
dc.title | Associations between exploratory dietary patterns and incident type 2 diabetes : a federated meta-analysis of individual participant data from 25 cohort studies | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001150085 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
Este item está licenciado na Creative Commons License
![](/themes/Mirage2Novo//images/lume/cc.png)
-
Artigos de Periódicos (39401)Ciências da Saúde (10592)