cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
dc.contributor.author | Schmitz, Carine Raquel Richter | pt_BR |
dc.contributor.author | Maurmann, Rafael Moura | pt_BR |
dc.contributor.author | Guma, Fátima Theresinha Costa Rodrigues | pt_BR |
dc.contributor.author | Bauer, Moises Evandro | pt_BR |
dc.contributor.author | Tuana, Florencia María Barbé | pt_BR |
dc.date.accessioned | 2023-04-05T03:47:49Z | pt_BR |
dc.date.issued | 2023 | pt_BR |
dc.identifier.issn | 1664-3224 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/256721 | pt_BR |
dc.description.abstract | Aging is associated with an increased incidence of autoimmune diseases, despite the progressive decline of immune responses (immunosenescence). This apparent paradox can be explained by the age-related chronic low-grade systemic inflammation (inflammaging) and progressive dysregulation of innate signaling. During cellular aging, there is an accumulation of damaged DNA in the cell’s cytoplasm, which serves as ubiquitous danger-associated molecule, promptly recognized by DNA sensors. For instance, the free cytoplasmic DNA can be recognized, by DNA-sensing molecules like cGAS-STING (cyclic GMP-AMP synthase linked to a stimulator of interferon genes), triggering transcriptional factors involved in the secretion of pro-inflammatory mediators. However, the contribution of this pathway to the aging immune system remains largely unknown. Here, we highlight recent advances in understanding the biology of the cGAS-STING pathway, its influence on the senescence-associated secretory phenotype (SASP), and its modulation of the immune system during sterile inflammation. We propose that this important stress sensor of DNA damage is also a trigger of immunosenescence and inflammaging. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Frontiers in immunology. [Lausanne]. Vol. 14 (2023), 1132653, 11 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Senescência celular | pt_BR |
dc.subject | Aging | en |
dc.subject | cGAS | en |
dc.subject | Imunossenescência | pt_BR |
dc.subject | Sistema imunitário | pt_BR |
dc.subject | Immunosenescence | en |
dc.subject | Inflammaging | en |
dc.subject | NF-kB | en |
dc.subject | SASP | en |
dc.subject | senescence | en |
dc.title | cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001165632 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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