Mostrar registro simples

dc.contributor.authorPereira, Mariana Codevila Buerept_BR
dc.contributor.authorRuschel, Brunapt_BR
dc.contributor.authorSchneider, Brunapt_BR
dc.contributor.authorMelgar, Vitor Salomão Gonçalves Melo dept_BR
dc.contributor.authorRech, Tatiana Helenapt_BR
dc.date.accessioned2023-07-04T03:49:08Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn2090-6439pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/259808pt_BR
dc.description.abstractSince the global coronavirus disease 2019 (COVID-19) pandemic began, findings indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might induce autoimmune disorders. Thrombotic thrombocytopenic purpura (TTP) is a devastating disease if not emergently treated. It presents with severe thrombocytopenia, microangiopathic hemolytic anemia, and neurologic findings with or without renal insufficiency. The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. The patient was initially treated with high-dose methylprednisolone and fresh frozen plasma until she was transferred to a tertiary care facility and plasma exchange was available. She evolved with a malignant ischemic vascular accident and was declared brain-dead 24 hours after the first plasma exchange section.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofCase reports in critical care. New York, NY. Vol. 2022 (Dec. 2022), 2934171, 5 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPúrpura trombocitopênica trombóticapt_BR
dc.subjectCOVID-19pt_BR
dc.subjectSARS-CoV-2pt_BR
dc.titleCOVID-19-induced fatal thrombotic thrombocytopenic purpura in a healthy young patient a case reportpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001168934pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples