COVID-19-induced fatal thrombotic thrombocytopenic purpura in a healthy young patient a case report
dc.contributor.author | Pereira, Mariana Codevila Buere | pt_BR |
dc.contributor.author | Ruschel, Bruna | pt_BR |
dc.contributor.author | Schneider, Bruna | pt_BR |
dc.contributor.author | Melgar, Vitor Salomão Gonçalves Melo de | pt_BR |
dc.contributor.author | Rech, Tatiana Helena | pt_BR |
dc.date.accessioned | 2023-07-04T03:49:08Z | pt_BR |
dc.date.issued | 2022 | pt_BR |
dc.identifier.issn | 2090-6439 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/259808 | pt_BR |
dc.description.abstract | Since the global coronavirus disease 2019 (COVID-19) pandemic began, findings indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might induce autoimmune disorders. Thrombotic thrombocytopenic purpura (TTP) is a devastating disease if not emergently treated. It presents with severe thrombocytopenia, microangiopathic hemolytic anemia, and neurologic findings with or without renal insufficiency. The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. We report a case of a healthy young patient presenting with the classic TTP pentad a few days after a diagnosis of COVID-19 confirmed by a positive SARS-CoV-2 RT-PCR test. The patient was initially treated with high-dose methylprednisolone and fresh frozen plasma until she was transferred to a tertiary care facility and plasma exchange was available. She evolved with a malignant ischemic vascular accident and was declared brain-dead 24 hours after the first plasma exchange section. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Case reports in critical care. New York, NY. Vol. 2022 (Dec. 2022), 2934171, 5 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Púrpura trombocitopênica trombótica | pt_BR |
dc.subject | COVID-19 | pt_BR |
dc.subject | SARS-CoV-2 | pt_BR |
dc.title | COVID-19-induced fatal thrombotic thrombocytopenic purpura in a healthy young patient a case report | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001168934 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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