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dc.contributor.authorRodrigues, Matheus Scarpattopt_BR
dc.contributor.authorMartins, Julia Nostranipt_BR
dc.contributor.authorPaula, Gabriela Cristina dept_BR
dc.contributor.authorVenturini, Ligia Milanezpt_BR
dc.contributor.authorSilveira, Gustavo de Bempt_BR
dc.contributor.authorStreck, Emilio Luizpt_BR
dc.contributor.authorBudni, Josianept_BR
dc.contributor.authorÁvila, Ricardo Andrez Machado dept_BR
dc.contributor.authorBem, Andreza Fabro dept_BR
dc.contributor.authorSilveira, Paulo Cesar Lockpt_BR
dc.contributor.authorOliveira, Jade dept_BR
dc.date.accessioned2024-10-19T06:14:47Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn0001-3765pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/280194pt_BR
dc.description.abstractCholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver’s superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue. Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice’s liver and heart, which was partially prevented by AuNP treatment.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 94, suppl. 4 (2022), e20211081, 16 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTranstornos do metabolismo dos lipídeospt_BR
dc.subjectAntioxidant moleculesen
dc.subjectHipercolesterolemiapt_BR
dc.subjectGold nanoparticlesen
dc.subjectHypercholesterolemiaen
dc.subjectEstresse oxidativopt_BR
dc.subjectNanopartículaspt_BR
dc.subjectOxidative stressen
dc.subjectPeripheral tissuesen
dc.titleEffects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissuespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001205609pt_BR
dc.type.originNacionalpt_BR


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