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dc.contributor.authorSouza, Pedro Augusto Almeidapt_BR
dc.contributor.authorOliveira, Cirilo Henrique dept_BR
dc.contributor.authorSouza, Luiz Paulo de Brito Oliveirapt_BR
dc.contributor.authorTeixeira, Thaynara de Jesuspt_BR
dc.contributor.authorCelestino, Iago Alvespt_BR
dc.contributor.authorPenha, Gabriele Barbosapt_BR
dc.contributor.authorSantos, Ronaldo Medeiros dospt_BR
dc.contributor.authorMendes, Wexley Mirandapt_BR
dc.contributor.authorRibeiro, Bergmann Moraispt_BR
dc.contributor.authorCampos, Fabrício Souzapt_BR
dc.contributor.authorRoehe, Paulo Michelpt_BR
dc.contributor.authorGuimarães, Natalia Rochapt_BR
dc.contributor.authorIani, Felipe Campos de Melopt_BR
dc.contributor.authorMartins, Ademir Jesuspt_BR
dc.contributor.authorAbreu, Filipe Vieira Santos dept_BR
dc.date.accessioned2024-10-19T06:19:04Zpt_BR
dc.date.issued2024pt_BR
dc.identifier.issn2076-0817pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/280253pt_BR
dc.description.abstractThe Chikungunya virus (CHIKV) presents global health challenges, with Brazil experiencing outbreaks since its introduction in 2014. In 2023, following a CHIKV outbreak in Minas Gerais (MG), social media was used to optimize an entomological survey aimed at identifying vectors and viral lineages and assessing insecticide resistance. Following Instagram posts, residents with suspected CHIKV infection were able to schedule mosquito aspirations. In total, 421 mosquitoes (165 Aedes aegypti and 256 Culex quinquefasciatus) were captured from 40 households in Salinas city (MG) and tested for the Dengue, Zika, and Chikungunya viruses through RT-qPCR. Twelve of 57 pools (10 Ae. aegypti and two Cx. quinquefasciatus) tested positive for CHIKV RNA. Viral RNA was also detected in the heads of nine Ae. aegypti, indicating viral dissemination but not in Cx. quinquefasciatus. Genome sequencing yielded the first near-complete genome from the 2023 outbreak, unveiling that the CHIKV strain belonged to the East/Central/South African (ECSA) genotype. Additionally, genetic analyses revealed high frequencies of kdr alleles, including in CHIKV-infected mosquitoes, suggesting resistance to pyrethroid insecticides in this Ae. aegypti population. Social media was important for guiding mosquito-capture efforts in CHIKV transmission hotspots, thus optimizing the opportunity for viral detection. These findings emphasize the urgent need for innovative vector studies and control strategies, as well as interdisciplinary approaches in public health interventions.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPathogens. Basel. Vol. 13, no. 6 (June 2024), 457, 14 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPyrethroiden
dc.subjectCulicidaept_BR
dc.subjectArbovíruspt_BR
dc.subjectSocial mediaen
dc.subjectMosquitos vetorespt_BR
dc.subjectPiretrinaspt_BR
dc.subjectCulexpt_BR
dc.subjectVírus Chikungunyapt_BR
dc.subjectAedespt_BR
dc.subjectSaúde públicapt_BR
dc.titleHigh frequencies of kdr mutation and Chikungunya infection in Aedes aegypti population from Minas Gerais, Brazilpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001205645pt_BR
dc.type.originEstrangeiropt_BR


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