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dc.contributor.authorGomes, Flavia Gobettipt_BR
dc.contributor.authorBoquett, Juliano Andrépt_BR
dc.contributor.authorKowalski, Thayne Woycinckpt_BR
dc.contributor.authorBremm, Joao Matheuspt_BR
dc.contributor.authorMichels, Marcus Silvapt_BR
dc.contributor.authorPretto, Luizapt_BR
dc.contributor.authorRockenbach, Marília Körbespt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorSanseverino, Maria Teresa Vieirapt_BR
dc.contributor.authorFraga, Lucas Rosapt_BR
dc.date.accessioned2024-12-05T06:50:35Zpt_BR
dc.date.issued2024pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/282011pt_BR
dc.description.abstractHuman reproduction goes through many challenges to its success and in many cases it fails. Cases of pregnancy loss are common outcomes for pregnancies, and implantation failures (IF) are common in assisted reproduction attempts. Although several risk factors have already been linked to adverse outcomes in reproduction, many cases remain without a definitive cause. Genetics of female reproduction is a field that may bring some pieces of this puzzle; however, there are no well-defined genes that might be related to the risk for recurrent pregnancy loss (RPL) and IF. Here, we present a literature review of the studies of genetic association in RPL and IF carried out in the Brazilian population and complemented with a database search to explore genes previously related to RPL and IF, where a search for genes previously involved in these conditions was performed in OMIM, HuGE, and CTD databases. Finally, we present the next steps for reproductive genetics investigation, through genomic sequencing analyses and discuss future plans in the study of RPL genetics. The combined strategy of looking for literature and databases is useful to raise hypotheses and to identify underexplored genes related to RPL and IF.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 46, no. 3, suppl. 1 (2024), e20230127, 12 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPerda do embriãopt_BR
dc.subjectEmbryo lossen
dc.subjectAborto espontâneopt_BR
dc.subjectEmbryologyen
dc.subjectGenomicsen
dc.subjectGenômicapt_BR
dc.subjectBiologia computacionalpt_BR
dc.subjectMiscarriageen
dc.subjectBioinformaticsen
dc.titleFrom bench to in silico and backwards : what have we done on genetics of recurrent pregnancy loss and implantation failure and where should we go next?pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001211848pt_BR
dc.type.originNacionalpt_BR


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