Biomateriais para formulações de base nanotecnológica visando terapia genética ocular
dc.contributor.author | Zorzi, Giovanni Konat | pt_BR |
dc.contributor.author | Schuh, Roselena Silvestri | pt_BR |
dc.contributor.author | Campos, Angela Machado de | pt_BR |
dc.contributor.author | Carvalho, Edison Luis Santana | pt_BR |
dc.contributor.author | Rott, Marilise Brittes | pt_BR |
dc.contributor.author | Teixeira, Helder Ferreira | pt_BR |
dc.date.accessioned | 2024-12-10T06:54:28Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/282232 | pt_BR |
dc.description.abstract | Gene therapy is a promising tool for the treatment of ocular diseases. Nevertheless, there are some import limitations, especially related to the ocular route and the characteristics of nucleic acids that must be overcome to ensure the success of the therapy. In this context, nanotechnology-based carriers such as nanoemulsions, nanoparticles, dendrimers and liposomes have risen as a promising vehicle for the protection of genetic material for vectoring the target cells. The success of such approach is closely related to the judicious selection of the biomaterial, where chemical structure and intermolecular interactions play a major role. So, this manuscript reviews some of the most important biomaterials, lipid and polymeric origin, employed in the manufacture of nanotechnologic carriers for ocular gene therapy involving interfering RNA (siRNA), antisense oligonucleotide (AS-ON) and plasmid DNA (pDNA). | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Química nova. São Paulo. Vol. 40, n. 1 (2017), p. 74-84 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Biomaterials | en |
dc.subject | Materiais biocompatíveis | pt_BR |
dc.subject | Ocular | en |
dc.subject | Terapia genética | pt_BR |
dc.subject | Nanotechnology | en |
dc.subject | Nanotecnologia | pt_BR |
dc.subject | Gene therapy | en |
dc.title | Biomateriais para formulações de base nanotecnológica visando terapia genética ocular | pt_BR |
dc.title.alternative | Biomaterials for nanotechnology-based formulations targeting ocular gene therapy | en |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001015093 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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