Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
dc.contributor.author | Malesuik, Marcelo Donadel | pt_BR |
dc.contributor.author | Paim, Clésio Soldateli | pt_BR |
dc.contributor.author | Steppe, Martin | pt_BR |
dc.contributor.author | Schapoval, Elfrides Eva Scherman | pt_BR |
dc.date.accessioned | 2013-07-02T01:43:22Z | pt_BR |
dc.date.issued | 2010 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/72886 | pt_BR |
dc.description.abstract | A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Química nova. São Paulo. Vol. 33, n. 3 (2010), p. 739-742 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Nitazoxanide | en |
dc.subject | Nitazoxanida | pt_BR |
dc.subject | Validação : Métodos de análise de fármacos | pt_BR |
dc.subject | UV-spectrophotometry | en |
dc.subject | Method validation | en |
dc.title | Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000753027 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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