Desenvolvimento e validação de método analítico para determinação de brinzolamida em suspensão oftálmica 1%
dc.contributor.advisor | Sfair, Letícia Lenz | pt_BR |
dc.contributor.author | Carvalho, Anelise Miglioranza de | pt_BR |
dc.date.accessioned | 2016-04-23T02:06:55Z | pt_BR |
dc.date.issued | 2011 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/139376 | pt_BR |
dc.description.abstract | Glaucoma is an optic neuropathy caused by multiple factors, characterized by progressive damage to the optic nerve and increased intraocular pressure, its main risk factor. Brinzolamide is a sulfonamide nonbacteriostatic derivative inhibitor of carbonic anhydrase II, which decreases the intraocular pressure by reducing aqueous humor formation. A stability-indicating HPLC method for the determination of brinzolamide in ophthalmic solution was developed and validated. Chromatographic analysis were performed in Phemomenex® C18 column (150x4.6 mm, particle size 5 μm). The mobile phase was composed of acetonitrile and 25 mM monobasic potassium phosphate buffer adjusted to pH 5.8 (40:60; v/v), flow rate of 1.0 mL/min and injection volume of 20 μL. The method was simple, rapid, specific, linear, precise, accurate and robust, suitable for use in routine quality control. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | por | pt_BR |
dc.rights | Open Access | en |
dc.subject | Brinzolamide | en |
dc.subject | Brinzolamida | pt_BR |
dc.subject | Suspensões oftálmicas | pt_BR |
dc.subject | Method validation | en |
dc.subject | Stability-indicating method | en |
dc.subject | Validação : Métodos de análise de fármacos | pt_BR |
dc.title | Desenvolvimento e validação de método analítico para determinação de brinzolamida em suspensão oftálmica 1% | pt_BR |
dc.type | Trabalho de conclusão de graduação | pt_BR |
dc.contributor.advisor-co | Steppe, Martin | pt_BR |
dc.identifier.nrb | 000865990 | pt_BR |
dc.degree.grantor | Universidade Federal do Rio Grande do Sul | pt_BR |
dc.degree.department | Faculdade de Farmácia | pt_BR |
dc.degree.local | Porto Alegre, BR-RS | pt_BR |
dc.degree.date | 2011 | pt_BR |
dc.degree.graduation | Farmácia | pt_BR |
dc.degree.level | graduação | pt_BR |
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