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dc.contributor.authorValiati, Fernanda Endlerpt_BR
dc.contributor.authorVasconcelos, Mailton França dept_BR
dc.contributor.authorLichtenfels, Martinapt_BR
dc.contributor.authorPetry, Fernanda dos Santospt_BR
dc.contributor.authorAlmeida, Rosa Maria Martins dept_BR
dc.contributor.authorSchwartsmann, Gilbertopt_BR
dc.contributor.authorSchroder, Nadjapt_BR
dc.contributor.authorFarias, Caroline Brunetto dept_BR
dc.contributor.authorRoesler, Rafaelpt_BR
dc.date.accessioned2019-02-15T02:34:10Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn1663-9812pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/188832pt_BR
dc.description.abstractGene expression related to the formation and modification of memories is regulated epigenetically by chromatin remodeling through histone acetylation. Memory formation and extinction can be enhanced by treatment with inhibitors of histone deacetylases (HDACs). The basolateral amygdala (BLA) is a brain area critically involved in regulating memory for inhibitory avoidance (IA). However, previous studies have not examined the effects of HDAC inhibition in the amygdala on memory for IA. Here we show that infusion of an HDAC inhibitor (HDACi), trichostatin A (TSA), into the BLA, enhanced consolidation of IA memory in rats when given at 1.5, 3, or 6 h posttraining, but not when the drug was infused immediately after training. In addition, intra-BLA administration of TSA immediately after retrieval delayed extinction learning. Moreover, we show that intra-BLA TSA in rats given IA training increased the levels of brain-derived neurotrophic factor in the dorsal hippocampus, but not in the BLA itself. These findings reveal novel aspects of the regulation of fear memory by epigenetic mechanisms in the amygdala.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in pharmacology. Lausanne. Vol. 8 (June 2017), article 415, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectHistona desacetilasespt_BR
dc.subjectHistone deacetylaseen
dc.subjectMemóriapt_BR
dc.subjectBrain-derived neurotrophic factoren
dc.subjectAmygdalaen
dc.subjectConsolidação da memóriapt_BR
dc.subjectHippocampusen
dc.subjectComplexo nuclear basolateral da amígdalapt_BR
dc.subjectHipocampopt_BR
dc.subjectMemory extinctionen
dc.subjectFator neurotrófico derivado do encéfalopt_BR
dc.subjectMemory consolidationen
dc.subjectEpigenômicapt_BR
dc.subjectPsicologia experimentalpt_BR
dc.titleAdministration of a histone deacetylase inhibitor into the basolateral amygdala enhances memory consolidation, delays extinction, and increases hippocampal BDNF levelspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001087076pt_BR
dc.type.originEstrangeiropt_BR


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